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Article

HLA-DRB1*1501 and VDR polymorphisms and survival of Mycobacterium tuberculosis in human macrophages exposed to inhalable microparticles.

Pharmacogenomics - 1 Apr 2013

Singh Amit K, Abhimanyu, Yadav Awadh B, Sharma Sandeep, Garg Rajiv, Bose Mridula, Misra Amit

Abstract excerpt

AIM: We examined whether HLA-DRB1*1501 and four VDR SNPs influence the macrophage response to infection with Mycobacterium tuberculosis (Mtb) via innate immune versus drug treatment or drug delivery mechanisms. MATERIALS & METHODS: Monocyte-derived macrophages from 24 healthy donors were infected with Mtb in vitro. Survival of intracellular bacilli and secretion of cytokines and nitric oxide by the infected cells...

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Source

Identifiers

PMID: 23556450
DOI: 10.2217/pgs.13.12

Genes

VDR
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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