Article
Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk.
PloS one - 1 Jan 2013
Lo Paulisally Hau Yi, Urabe Yuji, Kumar Vinod, Tanikawa Chizu, Koike Kazuhiko, Kato Naoya, Miki Daiki, Chayama Kazuaki, Kubo Michiaki, Nakamura Yusuke, Matsuda Koichi
Abstract excerpt
Hepatitis C virus (HCV) infection is the major cause of hepatocellular carcinoma (HCC) in Japan. We previously identified the association of SNP rs2596542 in the 5' flanking region of the MHC class I polypeptide-related sequence A (MICA) gene with the risk of HCV-induced HCC. In the current study, we performed detailed functional analysis of 12 candidate SNPs in the promoter region and found that a SNP rs2596538...
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