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Article

DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates.

PloS one - 1 Jan 2013

Paul Katja, Wang Minli, Mladenov Emil, Bencsik-Theilen Alena, Bednar Theresa, Wu Wenqi, Arakawa Hiroshi, Iliakis George

Abstract excerpt

Biochemical and genetic studies suggest that vertebrates remove double-strand breaks (DSBs) from their genomes predominantly by two non-homologous end joining (NHEJ) pathways. While canonical NHEJ depends on the well characterized activities of DNA-dependent protein kinase (DNA-PK) and LIG4/XRCC4/XLF complexes, the activities and the mechanisms of the alternative, backup NHEJ are less well characterized. Notably,...

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Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23555685
DOI: 10.1371/journal.pone.0059505
PMCID: PMC3610672

Genes

LIG1
LIG3
LIG4
XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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