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Article

Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent

1 Aug 2014

Abstract excerpt

Short dysfunctional telomeres are capable of fusion, generating dicentric chromosomes and initiating breakage-fusion-bridge cycles. Cells that escape the ensuing cellular crisis exhibit large-scale genomic rearrangements that drive clonal evolution and malignant progression. We demonstrate that there is an absolute requirement for fully functional DNA ligase III (LIG3), but not ligase IV (LIG4), to facilitate the...

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PMID: 25127141
DOI: 10.1016/j.celrep.2014.07.007

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