Article
A compendium of genome-wide associations for cancer: critical synopsis and reappraisal.
Journal of the National Cancer Institute - 16 Jun 2010
Ioannidis John P A, Castaldi Peter, Evangelou Evangelos
Abstract excerpt
Since 2007, genome-wide association (GWA) studies have identified numerous well-supported, novel genetic risk loci for common cancers; however, there are concerns that this technology is reaching its limits. We provide an overview of GWA-identified genetic associations with solid tumors. We simulated the distribution of population risk alleles for colorectal, prostate, testicular, and thyroid cancers based on...
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