Article
The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1.
The Journal of cell biology - 20 Dec 2004
Kadrmas Julie L, Smith Mark A, Clark Kathleen A, Pronovost Stephen M, Muster Nemone, Yates John R, Beckerle Mary C
Abstract excerpt
Cell adhesion and migration are dynamic processes requiring the coordinated action of multiple signaling pathways, but the mechanisms underlying signal integration have remained elusive. Drosophila embryonic dorsal closure (DC) requires both integrin function and c-Jun amino-terminal kinase (JNK) signaling for opposed epithelial sheets to migrate, meet, and suture. Here, we show that PINCH, a protein required for...
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