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Article

Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.

The Biochemical journal - 15 Aug 2013

Ke Ying, Ng Chai Ann, Hunter Mark J, Mann Stefan A, Heide Juliane, Hill Adam P, Vandenberg Jamie I

Abstract excerpt

Loss of Kv11.1 potassium channel function is the underlying cause of pathology in long-QT syndrome type 2, one of the commonest causes of sudden cardiac death in the young. Previous studies have identified the cytosolic PAS (Per/Arnt/Sim) domain as a hotspot for mutations that cause Kv11.1 trafficking defects. To investigate the underlying basis of this observation, we have quantified the effect of mutants on...

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PMID: 23721480
DOI: 10.1042/BJ20130328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.PMID 23721480Read ↗

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Structural properties of PAS domains from the KCNH potassium channels.Semantic proximity Read ↗

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Prediction of Kv11.1 potassium channel PAS-domain variants trafficking via machine learningSemantic proximity Read ↗

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