Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation

28 Mar 2023

Abstract excerpt

Recent epigenome-wide studies suggest an association between blood DNA methylation and kidney function. However, the pathological importance remains unclear. Here, we show that the homing endonuclease I-PpoI-induced DNA double-strand breaks in kidney glomerular podocytes cause proteinuria, glomerulosclerosis, and tubulointerstitial fibrosis with DNA methylation changes in blood cells as well as in podocytes....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Kidney Disease and Diabetes
Share to Renal Diseases and Glomerulopathies
Share to Renal Transplantation Outcomes and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36989112
DOI: 10.1016/j.celrep.2023.112302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylationPMID 36989112Read ↗

Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end stage renal diseaseSemantic proximity Read ↗

Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end stage renal diseaseSemantic proximity Read ↗

Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end-stage renal diseaseSemantic proximity Read ↗

Renal involvement in lupus is characterized by unique DNA methylation changes in naïve CD4+ T cellsSemantic proximity Read ↗

Significance of podocyte DNA damage and glomerular DNA methylation in CKD patients with proteinuriaSemantic proximity Read ↗

DNA methylation and whole-genome transcription analysis in CD4+ T cells from systemic lupus erythematosus patients with or without renal damageSemantic proximity Read ↗

Unraveling the epigenetic landscape of glomerular cells in kidney diseaseSemantic proximity Read ↗

Meta-analyses identify DNA methylation associated with kidney function and damageSemantic proximity Read ↗

The immune cell landscape in kidneys of lupus nephritis patientsSemantic proximity Read ↗

DNA Methylation Dysfunction in Chronic Kidney DiseaseSemantic proximity Read ↗

Advances in the Epigenetic Mechanisms of Diabetic Nephropathy PathogenesisSemantic proximity Read ↗

Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.