Article
TIPE2 Alleviates Systemic Lupus Erythematosus Through Regulating Macrophage Polarization.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2016
Li Feng, Zhu Xiaohua, Yang Yongsheng, Huang Lan, Xu Jinhua
Abstract excerpt
BACKGROUND/AIMS: We have recently shown that macrophage polarization may alter the pathogenesis and severity of systemic lupus erythematosus (SLE). However, a practical approach to modulate macrophage polarization in vivo is so far not available. In the current study, we aimed to use tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2) to regulate macrophage polarization in vitro and in vivo, and to...
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