Article

Chikungunya virus vaccine candidate incorporating synergistic mutations is attenuated and protects against virulent virus challenge

2021-10-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Chikungunya virus (CHIKV) is an arbovirus that periodically reemerges to cause large epidemics of arthritic disease. While the robust immunity elicited by live-attenuated virus (LAV) vaccine candidates makes them attractive, CHIKV vaccine development has been hampered by a high threshold for acceptable adverse events. <h4>Methods</h4> We evaluated the vaccine potential of a...

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Literature Corpus work: 908b9f37-339e-5226-83ac-e3edfabae419
DOI: 10.1101/2021.10.19.464869

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