Article
Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1992
Chen Y P, Djaffar I, Pidard D, Steiner B, Cieutat A M, Caen J P, Rosa J P
Abstract excerpt
Integrins are membrane receptors which mediate cell-cell or cell-matrix adhesion. Integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) acts as a fibrinogen receptor of platelets and mediates platelet aggregation. Platelet activation is required for alpha IIb beta 3 to shift from noncompetent to comp...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Base Sequence
- Chromatography, Affinity
- Female
- Fibrinogen
- Genetic Variation
- Humans
- Macromolecular Substances
- Male
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides