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Article

Knock-in mice bearing constitutively active αIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2020

Akuta Keigo, Kiyomizu Kazunobu, Kashiwagi Hirokazu, Kunishima Shinji, Nishiura Nobuko, Banno Fumiaki, Kokame Koichi, Kato Hisashi, Kanakura Yuzuru, Miyata Toshiyuki, Tomiyama Yoshiaki

Abstract excerpt

BACKGROUND: To date, several mutations that induce constitutive activation of integrin αIIbβ3 have been identified in congenital macrothrombocytopenia. Of these, αIIb(R995W) is the most prevalent mutation observed in Japanese patients with αIIbβ3-related congenital macrothrombocytopenia. OBJECTIVE AND METHODS: The present study aimed to explore the effects of constitutive activation of the αIIb(R995W) mutation on...

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PMID: 31691484
DOI: 10.1111/jth.14678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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