Article
Trans-Lesion DNA Polymerases May Be Involved in Yeast Meiosis.
G3 (Bethesda, Md.) - 9 Apr 2013
Arbel-Eden Ayelet, Joseph-Strauss Daphna, Masika Hagit, Printzental Oxana, Rachi Eléanor, Simchen Giora
Abstract excerpt
Trans-lesion DNA polymerases (TLSPs) enable bypass of DNA lesions during replication and are also induced under stress conditions. Being only weakly dependent on their template during replication, TLSPs introduce mutations into DNA. The low processivity of these enzymes ensures that they fall off their template after a few bases are synthesized and are then replaced by the more accurate replicative polymerase. We...
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