Article
Titrating haemophilia B phenotypes using siRNA strategy: evidence that antithrombotic activity is separated from bleeding liability.
Thrombosis and haemostasis - 1 Jun 2015
Metzger Joseph M, Tadin-Strapps Marija, Thankappan Anil, Strapps Walter R, DiPietro Marti, Leander Karen, Zhang Zuo, Shin Myung K, Levorse John, Desai Kunal, Xu Yiming, Lai KehDih, Wu Weizhen, Chen Zhu, Cai Tian-Quan, Jochnowitz Nina, Bentley Ross, Hoos Lizbeth, Zhou Yuchen, Sepp-Lorenzino Laura, Seiffert Dietmar, Andre Patrick
Abstract excerpt
Haemophilia A and B are characterised by a life-long bleeding predisposition, and several lines of evidence suggest that risks of atherothrombotic events may also be reduced. Establishing a direct correlation between coagulation factor levels, thrombotic risks and bleeding propensity has long been hampered by an inability to selectively and specifically inhibit coagulation factor levels. Here, the exquisite...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.