Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.

BMC research notes - 1 Apr 2013

Sabbaghian Nelly, Bahubeshi Amin, Shuen Andrew Y, Kanetsky Peter A, Tischkowitz Marc D, Nathanson Katherine L, Foulkes William D

Abstract excerpt

BACKGROUND: The RNase III enzyme DICER1 plays a central role in maturation of microRNAs. Identification of neoplasia-associated germ-line and somatic mutations in DICER1 indicates that mis-expression of miRNAs in cancer may result from defects in their processing. As part of a recent study of DIC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to Germ-Line Mutation
Share to MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms, Germ Cell and Embryonal

Share to Protein Structure, Tertiary

Share to Ribonuclease III

Share to Seminoma

Share to Testicular Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 23547758
DOI: 10.1186/1756-0500-6-127
PMCID: PMC3642033

Genes

DICER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23547758-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours.PMID 23547758Read ↗

DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.Semantic proximity Read ↗

Lack of pathogenic germline DICER1 variants in males with testicular germ-cell tumors.Semantic proximity Read ↗

DICER1 hotspot mutations in non-epithelial gonadal tumours.Semantic proximity Read ↗

Recurrent Somatic<i>DICER1</i>Mutations in Nonepithelial Ovarian CancersSemantic proximity Read ↗

DICER1 Syndrome: DICER1 Mutations in Rare CancersSemantic proximity Read ↗

Biallelic DICER1 mutations occur in Wilms tumoursSemantic proximity Read ↗

Spectrum of DICER1 Germline Pathogenic Variants in Ovarian Sertoli–Leydig Cell TumorSemantic proximity Read ↗

Intronic Germline DICER1 Variants in Patients With Sertoli-Leydig Cell Tumor.Semantic proximity Read ↗

Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis.Semantic proximity Read ↗

DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome.Semantic proximity Read ↗

Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame DICER1 deletion.Semantic proximity Read ↗

DICER1 Syndrome with an Intronic Germline Variant Causing Splice AlterationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.