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Article

Recurrent Somatic<i>DICER1</i>Mutations in Nonepithelial Ovarian Cancers

21 Dec 2011

Abstract excerpt

BACKGROUND: Germline truncating mutations in DICER1, an endoribonuclease in the RNase III family that is essential for processing microRNAs, have been observed in families with the pleuropulmonary blastoma-family tumor and dysplasia syndrome. Mutation carriers are at risk for nonepithelial ovarian tumors, notably sex cord-stromal tumors. METHODS: We sequenced the whole transcriptomes or exomes of 14 nonepithelial...

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PMID: 22187960
DOI: 10.1056/nejmoa1102903

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