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Biallelic DICER1 mutations occur in Wilms tumours

12 Apr 2013

Abstract excerpt

DICER1 is an endoribonuclease central to the generation of microRNAs (miRNAs) and short interfering RNAs (siRNAs). Germline mutations in DICER1 have been associated with a pleiotropic tumour predisposition syndrome and Wilms tumour (WT) is a rare manifestation of this syndrome. Three WTs, each in a child with a deleterious germline DICER1 mutation, were screened for somatic DICER1 mutations and were found to bear...

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PMID: 23620094
DOI: 10.1002/path.4196

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