Article
Lack of pathogenic germline DICER1 variants in males with testicular germ-cell tumors.
Cancer genetics - 1 Oct 2020
Vasta Lauren M, McMaster Mary L, Harney Laura A, Ling Alexander, Kim Jung, Harris Anne K, Carr Ann G, Damrauer Scott M, Rader Daniel J, Kember Rachel L, Kanetsky Peter A, Nathanson Katherine L, Pyle Louise C, Greene Mark H, Schultz Kris Ann, Stewart Douglas R
Abstract excerpt
BACKGROUND: Several studies have reported conflicting evidence on the inclusion of testicular germ cell tumors (TGCT) in the DICER1 tumor-predisposition phenotype. We evaluated the relationship between DICER1 and TGCT by reviewing scrotal ultrasounds of males with pathogenic germline variants in DICER1 and queried exome data from TGCT-affected men for DICER1 variants. METHODOLOGY: Fifty-four male DICER1-carriers...
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