Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy.

PloS one - 1 Jan 2013

Judson Robert N, Gray Stuart R, Walker Claire, Carroll Andrew M, Itzstein Cecile, Lionikas Arimantas, Zammit Peter S, De Bari Cosimo, Wackerhage Henning

Abstract excerpt

The aim of this study was to investigate the function of the Hippo pathway member Yes-associated protein (Yap, gene name Yap1) in skeletal muscle fibres in vivo. Specifically we bred an inducible, skeletal muscle fibre-specific knock-in mouse model (MCK-tTA-hYAP1 S127A) to test whether the over expression of constitutively active Yap (hYAP1 S127A) is sufficient to drive muscle hypertrophy or stimulate changes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Doxycycline
Share to Kyphosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Fibers, Skeletal

Share to Muscular Atrophy

Share to Muscular Diseases

Share to Necrosis

Share to Weight Loss

Share to YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23544078
DOI: 10.1371/journal.pone.0059622
PMCID: PMC3609830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy.PMID 23544078Read ↗

TAK1 regulates skeletal muscle mass, hypertrophic signaling, and metabolic homeostasis in male and female miceSemantic proximity Read ↗

Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy.Semantic proximity Read ↗

Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.Semantic proximity Read ↗

Disrupted autophagy undermines skeletal muscle adaptation and integritySemantic proximity Read ↗

Park7 expression influences myotube size and myosin expression in muscle.Semantic proximity Read ↗

Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophySemantic proximity Read ↗

L-tyrosine supplementation is not therapeutic for skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathySemantic proximity Read ↗

L-tyrosine supplementation does not ameliorate skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy.Semantic proximity Read ↗

Overexpression of the dominant-negative form of myostatin results in doubling of muscle-fiber number in transgenic medaka (Oryzias latipes).Semantic proximity Read ↗

Effect of dietary methionine level on muscle growth mechanisms in juvenile rainbow trout (Oncorhynchus mykiss)Semantic proximity Read ↗

Methodological issues limit interpretation of negative effects of satellite cell depletion on adult muscle hypertrophySemantic proximity Read ↗

Cardiac ankyrin repeat protein is a marker of skeletal muscle pathological remodellingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.