Article
L-tyrosine supplementation does not ameliorate skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy.
Scientific reports - 31 Jul 2018
Messineo Adriana M, Gineste Charlotte, Sztal Tamar E, McNamara Elyshia L, Vilmen Christophe, Ogier Augustin C, Hahne Dorothee, Bendahan David, Laing Nigel G, Bryson-Richardson Robert J, Gondin Julien, Nowak Kristen J
Abstract excerpt
L-tyrosine supplementation may provide benefit to nemaline myopathy (NM) patients, however previous studies are inconclusive, with no elevation of L-tyrosine levels in blood or tissue reported. We evaluated the ability of L-tyrosine treatments to improve skeletal muscle function in all three published animal models of NM caused by dominant skeletal muscle α-actin (ACTA1) mutations. Highest safe L-tyrosine...
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