Article

L-tyrosine supplementation is not therapeutic for skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy

2017-11-11

Abstract excerpt

<h4>ABSTRACT</h4> Nemaline myopathy (NM) is a skeletal muscle disorder with no curative treatment. Although L-tyrosine administration has been indicated to provide benefit to patients, previous studies have been limited due to sample size or not testing for raised L-tyrosine levels. We evaluated the efficacy of L-tyrosine treatment to improve skeletal muscle function in three animal models of NM caused by skeleta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b582ecea-f8f5-5812-b0df-a78d03c06d31
DOI: 10.1101/218016

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

L-tyrosine supplementation is not therapeutic for skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathyDOI 10.1101/218016Read

L-tyrosine supplementation does not ameliorate skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy.Semantic proximity Read

Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy.Semantic proximity Read

Testing of therapies in a novel nebulin nemaline myopathy model demonstrate a lack of efficacy.Semantic proximity Read

Standardization of zebrafish drug testing parameters for muscle diseasesSemantic proximity Read

Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafishSemantic proximity Read

Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish.Semantic proximity Read

Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function.Semantic proximity Read

Actin nemaline myopathy mouse reproduces disease, suggests other actin disease phenotypes and provides cautionary note on muscle transgene expression.Semantic proximity Read

Mouse models of dominant ACTA1 disease recapitulate human disease and provide insight into therapies.Semantic proximity Read

Neb: a zebrafish model of nemaline myopathy due to nebulin mutation.Semantic proximity Read

Myosin ATPase inhibition fails to rescue the metabolically dysregulated proteome of nebulin-deficient muscleSemantic proximity Read

NRAP reduction rescues sarcomere defects in nebulin-related nemaline myopathy.Semantic proximity Read