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Article

Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease.

Brain : a journal of neurology - 1 May 2013

Ryan Natalie S, Keihaninejad Shiva, Shakespeare Timothy J, Lehmann Manja, Crutch Sebastian J, Malone Ian B, Thornton John S, Mancini Laura, Hyare Harpreet, Yousry Tarek, Ridgway Gerard R, Zhang Hui, Modat Marc, Alexander Daniel C, Rossor Martin N, Ourselin Sebastien, Fox Nick C

Abstract excerpt

Amyloid imaging studies of presymptomatic familial Alzheimer's disease have revealed the striatum and thalamus to be the earliest sites of amyloid deposition. This study aimed to investigate whether there are associated volume and diffusivity changes in these subcortical structures during the presymptomatic and symptomatic stages of familial Alzheimer's disease. As the thalamus and striatum are involved in neural...

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Identifiers

PMID: 23539189
DOI: 10.1093/brain/awt065
PMCID: PMC3634199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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