Article
COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependence.
Addiction biology - 1 Mar 2013
Schellekens Arnt F A, Franke Barbara, Ellenbroek Bart, Cools Alexander, de Jong Cor A J, Buitelaar Jan K, Verkes Robbert-Jan
Abstract excerpt
Genetic factors and childhood adverse experiences contribute to the vulnerability to alcohol dependence. However, empirical data on the interplay between specific genes and adverse experiences are few. The COMT Val158Met and DRD2/ANKK1 Taq1A genotypes have been suggested to affect both stress sensitivity and the risk for alcohol dependence. This study tested the hypothesis that genetic variation in COMT Val158Met...
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