Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility.

Genes and immunity - 1 Jun 2013

Wang C, Ahlford A, Laxman N, Nordmark G, Eloranta M-L, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson A A, Truedsson L, Rantapää-Dahlqvist S, Sjöwall C, Sandling J K, Rönnblom L, Syvänen A-C

Abstract excerpt

The type I interferon system genes IKBKE and IFIH1 are associated with the risk of systemic lupus erythematosus (SLE). To identify the sequence variants that are able to account for the disease association, we resequenced the genes IKBKE and IFIH1. Eighty-six single-nucleotide variants (SNVs) wit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to I-kappa B Kinase

Share to Interferon-Induced Helicase, IFIH1

Share to Lupus Erythematosus, Systemic

Share to Protein Binding

Share to RNA Splicing Factors

Source

Identifiers

PMID: 23535865
DOI: 10.1038/gene.2013.9

Genes

IFIH1
IKBKE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23535865-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility.PMID 23535865Read ↗

Autoimmune disease associated IFIH1 single nucleotide polymorphism related with IL-18 serum levels in Chinese systemic lupus erythematosus patients.Semantic proximity Read ↗

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosusSemantic proximity Read ↗

A Comprehensive Analysis of Type I Interferon Risk Gene Signatures in Systemic Lupus Erythematosus.Semantic proximity Read ↗

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.Semantic proximity Read ↗

Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis.Semantic proximity Read ↗

Association study of IFIH1 rs1990760 polymorphism with systemic lupus erythematosus in a Chinese population.Semantic proximity Read ↗

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.Semantic proximity Read ↗

Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.Semantic proximity Read ↗

Genetic Polymorphisms in Genes Involved in the Type I Interferon System (IFIH1/MDA-5, TNFAIP3/A20, and STAT4): Association with SLE Risk in Egyptian Children and AdolescentsSemantic proximity Read ↗

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.Semantic proximity Read ↗

Identification of LncRNA Linc00513 Containing Lupus-Associated Genetic Variants as a Novel Regulator of Interferon Signaling PathwaySemantic proximity Read ↗

The decreased expression of IKBKE in systemic lupus erythematosus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.