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Article

Autoimmune disease associated IFIH1 single nucleotide polymorphism related with IL-18 serum levels in Chinese systemic lupus erythematosus patients.

Scientific reports - 21 Jun 2018

Zhang Junlong, Liu Xinle, Meng Yanming, Wu Hengxu, Wu Yongkang, Yang Bin, Wang Lanlan

Abstract excerpt

Systemic lupus erythematosus (SLE) has heterogeneous clinical manifestations. IFIH1 (interferon induced with helicase C domain 1) as one of antiviral helicase genes mediating type I interferon production, plays an essential role in the pathogenesis of SLE. The gene variants in IFIH1 could abnormally activate antiviral defenses and increased type I interferon signaling. The present study aimed to validate...

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Source

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Identifiers

PMID: 29930297
DOI: 10.1038/s41598-018-27782-7
PMCID: PMC6013496

Genes

IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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