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Article

Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis.

Genetics and molecular research : GMR - 24 Oct 2016

Silva J De Azevedo, Lima S C, Addobbati C, Moura R, Brandão L A Cavalcanti, Pancoto J A Trés, Donadi E A, Crovella S, Sandrin-Garcia P

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral tolerance. Interferon-induced helicase C domain 1 (IFIH1) activates and modulates IFN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interferon-Induced Helicase, IFIH1

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Source

Identifiers

PMID: 27813554
DOI: 10.4238/gmr15048008

Genes

IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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