Article
Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer.
PloS one - 1 Jan 2013
Schick Ursula M, McDavid Andrew, Crane Paul K, Weston Noah, Ehrlich Kelly, Newton Katherine M, Wallace Robert, Bookman Ebony, Harrison Tabitha, Aragaki Aaron, Crosslin David R, Wang Sophia S, Reiner Alex P, Jackson Rebecca D, Peters Ulrike, Larson Eric B, Jarvik Gail P, Carlson Christopher S
Abstract excerpt
Chromosomal abnormalities provide clinical utility in the diagnosis and treatment of hematologic malignancies, and may be predictive of malignant transformation in individuals without apparent clinical presentation of a hematologic cancer. In an effort to confirm previous reports of an association between clonal mosaicism and incident hematologic cancer, we applied the anomDetectBAF algorithm to call chromosomal...
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