Article
Genomic studies have identified multiple mechanisms of genetic changes in Waldenström macroglobulinemia.
Clinical lymphoma, myeloma & leukemia - 1 Apr 2013
Poulain Stéphanie, Herbaux Charles, Bertrand Elisabeth, Decambron Audrey, Fouquet Guillemette, Boyle Eileen, Gay Julie, Manier Salomon, Duthilleul Patrick, Roumier Christophe, Leleu Xavier
Abstract excerpt
The pathophysiology of Waldenström macroglobulinemia (WM), a lymphoproliferative disorder characterized by lymphoplasmacytic bone marrow infiltration associated with serum IgM paraprotein, is rather unclear; however, progress has been made in recent years to better determine the genetic profile of WM tumor cells. Studies based on high-throughput genomic analyses-including single-nucleotide polymorphism array...
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