Article
Effects of intracellular Mn on the radiation resistance of the halophilic archaeon Halobacterium salinarum.
Extremophiles : life under extreme conditions - 1 May 2013
Webb Kimberly M, Yu Jerry, Robinson Courtney K, Noboru Tomiya, Lee Yuan C, DiRuggiero Jocelyne
Abstract excerpt
Ionizing radiation (IR) is of particular interest in biology because its exposure results in severe oxidative stress to the cell's macromolecules. Our recent work with extremophiles supports the idea that IR resistance is most likely achieved by a metabolic route, effected by manganese (Mn) antioxidants. Biochemical analysis of "super-IR resistant" mutants of H. salinarum, evolved over multiple cycles of exposure...
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