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Article

Coordination of frontline defense mechanisms under severe oxidative stress.

Molecular systems biology - 1 Jul 2010

Kaur Amardeep, Van Phu T, Busch Courtney R, Robinson Courtney K, Pan Min, Pang Wyming Lee, Reiss David J, DiRuggiero Jocelyne, Baliga Nitin S

Abstract excerpt

Complexity of cellular response to oxidative stress (OS) stems from its wide-ranging damage to nucleic acids, proteins, carbohydrates, and lipids. We have constructed a systems model of OS response (OSR) for Halobacterium salinarum NRC-1 in an attempt to understand the architecture of its regulatory network that coordinates this complex response. This has revealed a multi-tiered OS-management program to...

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Identifiers

PMID: 20664639
DOI: 10.1038/msb.2010.50
PMCID: PMC2925529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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