Article
Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair.
eLife - 4 Mar 2014
Byrne Rose T, Klingele Audrey J, Cabot Eric L, Schackwitz Wendy S, Martin Jeffrey A, Martin Joel, Wang Zhong, Wood Elizabeth A, Pennacchio Christa, Pennacchio Len A, Perna Nicole T, Battista John R, Cox Michael M
Abstract excerpt
By directed evolution in the laboratory, we previously generated populations of Escherichia coli that exhibit a complex new phenotype, extreme resistance to ionizing radiation (IR). The molecular basis of this extremophile phenotype, involving strain isolates with a 3-4 order of magnitude increase in IR resistance at 3000 Gy, is now addressed. Of 69 mutations identified in one of our most highly adapted isolates,...
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