Article
Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation.
Neoplasia (New York, N.Y.) - 1 Dec 2017
Wang Jing, Deng Rong, Cui Nan, Zhang Hailong, Liu Tianqi, Dou Jinzhuo, Zhao Xian, Chen Ran, Wang Yanli, Yu Jianxiu, Huang Jian
Abstract excerpt
Src, a non-receptor tyrosine kinase protein, plays a critical role in cell proliferation and tumorigenesis. SUMOylation, a reversible ubiquitination-like post-translational modification, is vital for tumor progression. Here, we report that the Src protein can be SUMOylated at lysine 318 both in vitro and in vivo. Hypoxia can induce a decrease of Src SUMOylation along with an increase of Y419 phosphorylation, a...
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