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Article

Transgenic overexpression of ribonucleotide reductase improves cardiac performance.

Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013

Nowakowski Sarah G, Kolwicz Stephen C, Korte Frederick Steven, Luo Zhaoxiong, Robinson-Hamm Jacqueline N, Page Jennifer L, Brozovich Frank, Weiss Robert S, Tian Rong, Murry Charles E, Regnier Michael

Abstract excerpt

We previously demonstrated that cardiac myosin can use 2-deoxy-ATP (dATP) as an energy substrate, that it enhances contraction and relaxation with minimal effect on calcium-handling properties in vitro, and that contractile enhancement occurs with only minor elevation of cellular [dATP]. Here, we report the effect of chronically enhanced dATP concentration on cardiac function using a transgenic mouse that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23530224
DOI: 10.1073/pnas.1220693110
PMCID: PMC3625337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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