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Article

Epigenetic regulation of CD34 and HIF1A expression during the differentiation of human mast cells.

Immunogenetics - 1 Jun 2013

Walczak-Drzewiecka Aurelia, Salkowska Anna, Ratajewski Marcin, Dastych Jaroslaw

Abstract excerpt

Mast cells differentiate from circulating pluripotent hematopoietic progenitors. During this differentiation, the progenitor cells are exposed to changes in oxygen availability. HIF1A is the major sensor of oxygen concentration in mammalian cells. We investigated the expression of HIF1A during the in vitro differentiation of peripheral blood-derived progenitors into human mast cells. In a series of experiments,...

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Share to Antigens, CD34
Share to Chymases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Mast Cells

Share to Methylation

Share to Receptors, IgE

Source

Open in PubMed Open full text

Identifiers

PMID: 23529663
DOI: 10.1007/s00251-013-0695-8
PMCID: PMC3651818

Genes

CMA1
TPSB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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