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Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors

2 May 2022

Abstract excerpt

Mast cell accumulation is a hallmark of a number of diseases, including allergic asthma and systemic mastocytosis. Immunoglobulin E-mediated crosslinking of the FcεRI receptors causes mast cell activation and contributes to disease pathogenesis. The mast cell lineage is one of the least studied among the hematopoietic cell lineages, and controversies remain about whether FcεRI expression appears during the mast...

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PMID: 35500226
DOI: 10.1182/bloodadvances.2022006969

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