Article
Early development and functional properties of tryptase/chymase double-positive mast cells from human pluripotent stem cells.
Journal of molecular cell biology - 7 May 2021
Bian Guohui, Gu Yanzheng, Xu Changlu, Yang Wenyu, Pan Xu, Chen Yijin, Lai Mowen, Zhou Ya, Dong Yong, Mao Bin, Zhou Qiongxiu, Chen Bo, Nakathata Tatsutoshi, Shi Lihong, Wu Min, Zhang Yonggang, Ma Feng
Abstract excerpt
Mast cells (MCs) play a pivotal role in the hypersensitivity reaction by regulating the innate and adaptive immune responses. Humans have two types of MCs. The first type, termed MCTC, is found in the skin and other connective tissues and expresses both tryptase and chymase, while the second, termed MCT, which only expresses tryptase, is found primarily in the mucosa. MCs induced from human adult-type CD34+ cells...
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