Article

Codon Usage in SARS-CoV-2 Spike: Global Dominance of the Suboptimal TAG Stop Codon and Amino Acid Specific Biases from 9.3 Million Genomes

2025-09-01

Abstract excerpt

We analyzed approximately 9.3 million global SARS-CoV-2 genomes to characterize codon usage in the spike gene. Sequences were processed in 188 chunks of ~50,000 genomes each, with results aggregated into tab-separated value (TSV) files. Standard indices including relative synonymous codon usage (RSCU), effective number of codons (ENc), stop codon distribution, and GC3s were computed. The TAG stop codon predominate...

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Literature Corpus work: bc7e63e5-a865-53e2-876b-59cc3e494518
DOI: 10.20944/preprints202509.0044.v1

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