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Article

Functional impact of ABCB1 variants on interactions between P-glycoprotein and methadone.

PloS one - 1 Jan 2013

Hung Chin-Chuan, Chiou Mu-Han, Teng Yu-Ning, Hsieh Yow-Wen, Huang Chieh-Liang, Lane Hsien-Yuan

Abstract excerpt

Methadone is a widely used substitution therapy for opioid addiction. Large inter-individual variability has been observed in methadone maintenance dosages and P-glycoprotein (P-gp) was considered to be one of the major contributors. To investigate the mechanism of P-gp's interaction with methadone, as well as the effect of genetic variants on the interaction, Flp-In™-293 cells stably transfected with various...

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Source

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Identifiers

PMID: 23527191
DOI: 10.1371/journal.pone.0059419
PMCID: PMC3602015

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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