Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth.

doi:10.1007/s11060-013-1112-8

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Article

Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth.

Journal of neuro-oncology - 1 Jun 2013

Suswam Esther A, Shacka John J, Walker Kiera, Lu Liang, Li Xuelin, Si Ying, Zhang Xiaowen, Zheng Lei, Nabors L Burt, Cao Heping, King Peter H

Abstract excerpt

Malignant gliomas rely on the production of certain critical growth factors including VEGF, interleukin (IL)-6 and IL-8, to fuel rapid tumor growth, angiogenesis, and treatment resistance. Post-transcriptional regulation through adenine and uridine-rich elements of the 3' untranslated region is one mechanism for upregulating these and other growth factors. In glioma cells, we have shown that the...

Topics

3' Untranslated Regions
Apoptosis
Blotting, Western
Brain Neoplasms
Cell Proliferation
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Glioma
Humans
Immunoprecipitation
Interleukin-6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-8

Mutation

Phosphorylation

RNA Stability

RNA, Messenger

Real-Time Polymerase Chain Reaction

Reverse Transcriptase Polymerase Chain Reaction

Source

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Identifiers

PMID: 23525947
DOI: 10.1007/s11060-013-1112-8
PMCID: PMC3679321

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