Article
Tristetraprolin exerts tumor suppressive functions on the tumorigenesis of glioma by targeting IL-13.
International immunopharmacology - 1 Oct 2016
Zeng Bo, Zhu Danhua, Su Zhipeng, Li Zequn, Yu Zhengquan
Abstract excerpt
The RNA-binding protein tristetraprolin (TTP) is an adenine/uridine (AU)-rich elements (AREs)-binding protein that can induce the decay of AREs containing mRNAs. In this study, we demonstrated that TTP is significantly down-regulated in human glioma tissue samples and cell lines. It is also associated with diminished survival in glioma patients. Gain- and loss-of-function studies demonstrated that TTP inhibited...
Topics
- Brain Neoplasms
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Engineering
- Glioma
- Humans
- Interleukin-13
- Male