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Article

Tristetraprolin exerts tumor suppressive functions on the tumorigenesis of glioma by targeting IL-13.

International immunopharmacology - 1 Oct 2016

Zeng Bo, Zhu Danhua, Su Zhipeng, Li Zequn, Yu Zhengquan

Abstract excerpt

The RNA-binding protein tristetraprolin (TTP) is an adenine/uridine (AU)-rich elements (AREs)-binding protein that can induce the decay of AREs containing mRNAs. In this study, we demonstrated that TTP is significantly down-regulated in human glioma tissue samples and cell lines. It is also associated with diminished survival in glioma patients. Gain- and loss-of-function studies demonstrated that TTP inhibited...

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Source

Identifiers

PMID: 27424080
DOI: 10.1016/j.intimp.2016.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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