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Transcriptional Regulation of Tristetraprolin by Transforming Growth Factor-β in Human T Cells

1 Aug 2003

Abstract excerpt

Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine that plays a critical role in modulating immune response and inflammation. We employed the Affymetrix cDNA microarray system to detect genes whose expression is regulated by TGF-beta1 in a human T cell line HuT78. Tristetraprolin (TTP), a protein involved in the degradation of tumor necrosis factor-alpha (TNF-alpha) mRNA, was found to be...

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PMID: 12754205
DOI: 10.1074/jbc.m304856200

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