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Article

Tumor suppressor p53 plays a key role in induction of both tristetraprolin and let-7 in human cancer cells.

Nucleic acids research - 1 Jun 2013

Lee Ji Young, Kim Hyo Jeong, Yoon Nal Ae, Lee Won Hyeok, Min Young Joo, Ko Byung Kyun, Lee Byung Ju, Lee Aran, Cha Hee Jeong, Cho Wha Ja, Park Jeong Woo

Abstract excerpt

Tristetraprolin (TTP) and let-7 microRNA exhibit suppressive effects on cell growth through down-regulation of oncogenes. Both TTP and let-7 are often repressed in human cancers, thereby promoting oncogenesis by derepressing their target genes. However, the precise mechanism of this repression is unknown. We here demonstrate that p53 stimulated by the DNA-damaging agent doxorubicin (DOX) induced the expression of...

Topics

Adenocarcinoma
Cell Line, Tumor
Cell Proliferation
Colonic Neoplasms
Doxorubicin
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs
Mutation
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Binding Proteins

Tristetraprolin

Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 23595149
DOI: 10.1093/nar/gkt222
PMCID: PMC3675463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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