Article
MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.
The EMBO journal - 24 Mar 2004
Stoecklin Georg, Stubbs Tiffany, Kedersha Nancy, Wax Stephen, Rigby William F C, Blackwell T Keith, Anderson Paul
Abstract excerpt
Stress granules (SGs) are dynamic cytoplasmic foci at which stalled translation initiation complexes accumulate in cells subjected to environmental stress. SG-associated proteins such as TIA-1, TIAR and HuR bind to AU-rich element (ARE)-containing mRNAs and control their translation and stability. Here we show that tristetraprolin (TTP), an ARE-binding protein that destabilizes ARE-mRNAs, is recruited to SGs that...
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