Article
Generation of a novel monoclonal antibody WMab-1 specific for IDH2-R172W mutation.
Biochemical and biophysical research communications - 19 Apr 2013
Kato Yukinari, Kaneko Mika Kato
Abstract excerpt
Isocitrate dehydrogenase 2 (IDH2) mutations have been detected in gliomas, cartilaginous tumors, and acute myeloid leukemias. IDH2 mutations are specific to a single codon in the conserved and functionally important Arginine 172 (R172) or Arginine 140 (R140). To date, we have established specific...
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