Article
Establishment of novel monoclonal antibodies KMab-1 and MMab-1 specific for IDH2 mutations.
Biochemical and biophysical research communications - 1 Mar 2013
Kaneko Mika Kato, Morita Shunpei, Tsujimoto Yuta, Yanagiya Ryo, Nasu Kana, Sasaki Hiroko, Hozumi Yasukazu, Goto Kaoru, Natsume Atsushi, Watanabe Mika, Kumabe Toshihiro, Takano Shingo, Kato Yukinari
Abstract excerpt
Isocitrate dehydrogenase 1/2 (IDH1/2) mutations have been detected in gliomas, cartilaginous tumors, and leukemias. IDH1/2 mutations are early and frequent genetic alterations, are specific to a single codon in the conserved and functionally important Arginine 132 (R132) in IDH1 and Arginine 172 (R172) in IDH2. We previously established several monoclonal antibodies (mAbs), which are specific for IDH1 mutations:...
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