Article
Novel monoclonal antibodies GMab-r1 and LMab-1 specifically recognize IDH1-R132G and IDH1-R132L mutations.
Monoclonal antibodies in immunodiagnosis and immunotherapy - 1 Jun 2013
Kaneko Mika Kato, Tsujimoto Yuta, Hozumi Yasukazu, Goto Kaoru, Kato Yukinari
Abstract excerpt
Isocitrate dehydrogenase 1 (IDH1) catalyzes the oxidative carboxylation of isocitrate to α-ketoglutarate in cytosol. IDH1 mutations, which are specific to a single codon in the conserved and functionally important Arginine 132 (R132), result in the ability of the enzyme to catalyze the reduced NADP-dependent reduction of α-ketoglutarate to onco-metabolite R(-)-2-hydroxyglutarate (2-HG). IDH1 mutations, which are...
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