Article
A vaccine targeting mutant IDH1 induces antitumour immunity.
Nature - 21 Aug 2014
Schumacher Theresa, Bunse Lukas, Pusch Stefan, Sahm Felix, Wiestler Benedikt, Quandt Jasmin, Menn Oliver, Osswald Matthias, Oezen Iris, Ott Martina, Keil Melanie, Balß Jörg, Rauschenbach Katharina, Grabowska Agnieszka K, Vogler Isabel, Diekmann Jan, Trautwein Nico, Eichmüller Stefan B, Okun Jürgen, Stevanović Stefan, Riemer Angelika B, Sahin Ugur, Friese Manuel A, Beckhove Philipp, von Deimling Andreas, Wick Wolfgang, Platten Michael
Abstract excerpt
Monoallelic point mutations of isocitrate dehydrogenase type 1 (IDH1) are an early and defining event in the development of a subgroup of gliomas and other types of tumour. They almost uniformly occur in the critical arginine residue (Arg 132) in the catalytic pocket, resulting in a neomorphic enzymatic function, production of the oncometabolite 2-hydroxyglutarate (2-HG), genomic hypermethylation, genetic...
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