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Article

Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone.

Cancer science - 1 Jun 2014

Kato Kaneko Mika, Liu Xing, Oki Hiroharu, Ogasawara Satoshi, Nakamura Takuro, Saidoh Noriko, Tsujimoto Yuta, Matsuyama Yuka, Uruno Akira, Sugawara Masato, Tsuchiya Takashi, Yamakawa Mitsunori, Yamamoto Masayuki, Takagi Michiaki, Kato Yukinari

Abstract excerpt

Giant cell tumors of bone (GCTB) are benign and locally destructive tumors that include osteoclast-type multinuclear giant cells. No available treatment is definitively effective in curing GCTB, especially in surgically unresectable cases. Isocitrate dehydrogenase (IDH) mutations have been report...

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Source

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Identifiers

PMID: 24898068
DOI: 10.1111/cas.12413
PMCID: PMC4317903

Genes

IDH1
IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24898068-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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