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Article

A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.

Molecular cell - 11 Apr 2013

Jiao Xinfu, Chang Jeong Ho, Kilic Turgay, Tong Liang, Kiledjian Megerditch

Abstract excerpt

Recently, we reported that two homologous yeast proteins, Rai1 and Dxo1, function in a quality control mechanism to clear cells of incompletely 5' end-capped messenger RNAs (mRNAs). Here, we report that their mammalian homolog, Dom3Z (referred to as DXO), possesses pyrophosphohydrolase, decapping, and 5'-to-3' exoribonuclease activities. Surprisingly, we found that DXO preferentially degrades defectively capped...

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Source

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Identifiers

PMID: 23523372
DOI: 10.1016/j.molcel.2013.02.017
PMCID: PMC3630477

Genes

DXO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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