Article
A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity.
Journal of virology - 1 Mar 1999
Salzwedel K, West J T, Hunter E
Abstract excerpt
Mutations were introduced into the ectodomain of the human immunodeficiency virus type 1 (HIV-1) transmembrane envelope glycoprotein, gp41, within a region immediately adjacent to the membrane-spanning domain. This region, which is predicted to form an alpha-helix, contains highly conserved hydro...
Topics
- Amino Acid Sequence
- Animals
- CD4 Antigens
- COS Cells
- Cell Fusion
- Conserved Sequence
- Gene Products, env
- HIV Envelope Protein gp41
- HIV-1
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Structure-Activity Relationship
- Tryptophan